eMedinewS8th February 2014, Saturday

Dr K K AggarwalPadma Shri and Dr B C Roy National Awardee

Dr KK Aggarwal

President, Heart Care Foundation of India; Sr Consultant Physician, Cardiologist & Dean Medical Education Moolchand Medcity; Editor in Chief IJCP Group, National Vice President Elect, Indian Medical Association; Chairman Ethical Committee Delhi Medical Council, Hony. Visiting Professor (Clinical Research) DIPSAR; Chairman (Delhi Chapter) International Medical Sciences Academy (March 10–13); Hony Director IMA AKN Sinha Institute (08–09); Hony Finance Secretary National IMA (07–08); Chairman IMA Academy of Medical Specialties (06–07); President Delhi Medical Association (05–06), President IMA New Delhi Branch (94–95, 02–04);
For updates follow at
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A Soda a Day Ups CVD Risk by 30%: NHANES Study

American adults consume on average about 15% of their calories from sugars added to foods during processing, with a whopping 37% of the added sugar consumed in sugar–sweetened beverages, suggests an analysis of data extending back about 25 years.

Regularly drinking as little as one 12–ounce sugary soda a day may increase the risk of cardiovascular disease by about 30%—independent of total calories, obesity, or other risk factors, as per a study in JAMA Internal Medicine.

Epidemiologic studies have linked high consumption of added sugar with an increased risk of type 2 diabetes, obesity, and hypertension.

The American Heart Association recommends less than 100 calories a day (about 5% of total daily calories) for women and 150 calories a day (about 7.5% of total daily calories) for men from added sugars.

The risk of CVD mortality becomes elevated once added sugar intake surpasses 15% of daily calories—equivalent to drinking one 20–ounce Mountain Dew soda in a 2000-calorie daily diet.

The risk rises exponentially as sugar intake increases, peaking with a fourfold increased risk of CVD death for individuals who consume one–third or more of their daily calories in added sugar.

eMedinewS Recommendations

  1. Do not consume > 80 ml of cold drinks in a day
  2. Avoid sweets containing > 30% sugar.

Breaking News

An Afghan boy age 3 is A+ polio case is reported to be admitted in a Private Delhi Hospital for Lung and Infants.

Debate: Medical Tourism needs Caution in National Interest

Dr K K Aggarwal on Zee TV

cpr10 Mantra The CPR 10 Mantra is – "within 10 minutes of death, earlier the better; at least for the next 10 minutes, longer the better; compress the centre of the chest of the dead person continuously and effectively with a speed of 10×10 i.e. 100 per minute."

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VIP’s on CPR 10 Mantra Video
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Ringtone – CPR 10 Mantra Hindi
Ringtone – CPR 10 Mantra English

Five Types of People from Nastik to Astik

sprritual blog

Following are the five types of people

1. Nastik – the one who believes in God.
2. Astik – for whom God exists.
3. For them the God also exists in them (I and the God are the same)
4. Tatvamase (God not only exists in me but also in you)
5. God is in everybody

People who believe that God exists are fearful people and they always fear God. People who see God in themselves, live a disciplined Satvik life and do not indulge in activities which are not God-friendly.

People who believe that God is not only in me but you also, treat every person the same way as they treat themselves.

People for whom God is everywhere always work for the welfare of the society.

cardiology news

Happiness is a Voyage

We convince ourselves that life will be better once we are married, have a baby, then another. Then we get frustrated because our children are not old enough and that all will be well when they are older. Then we are frustrated because they reach adolescence and we must deal with them. Surely we’ll be happier when they grow out of the teen years.

We tell ourselves our life will be better when our spouse gets his/her act together, when we have a nicer car, when we can take a vacation, when we finally retire. The truth is that there is no better time to be happy than right now.

If not, then when? Your life will always be full of challenges. It is better to admit as much and to decide to be happy in spite of it all. For the longest time, it seemed that life was about to start. Real life…

But there was always some obstacle along the way, an ordeal to get through, some work to be finished, some time to be given, a bill to be paid. Then life would start. I finally came to understand that those obstacles were life. That point of view helped me see that there isn’t any road to happiness.

Happiness IS the road. So, enjoy every moment.

Stop waiting for school to end, for a return to school, to lose ten pounds, to gain ten pounds, for work to begin, to get married, for Friday evening, for Sunday morning, waiting for a new car, for your mortgage to be paid off, for spring, for summer, for fall, for winter, for the first or the fifteenth of the month, for your song to be played on the radio, to die, to be reborn… before deciding to be happy.

Happiness is a voyage, not a destination. There is no better time to be happy than… NOW! Live and enjoy the moment.

News Around The Globe

6th International Conference "Recent Advances in Cardiovascular Sciences" 31st January &1st February, 2014

Prof. Tejal Gandhi, Ph.D
Professor and Principal, Anand Pharmacy College, Anand
Dean (Pharmacy), Gujarat Technological University, Gujarat


Dr. Tejal R Gandhi is a senior Research Scientist and Academician, with over 20 years of experience in Pharmaceutical Research, particularly in the areas of Cardiovascular and Metabolic Disorders. After completion of her B.Pharm. in 1990, Dr Gandhi had the invaluable opportunity to conduct research work at the L M College of Pharmacy, under the able guidance of eminent researcher and scientist, Dr. Ramesh K. Goyal. Dr Gandhi was selected as a Senior Research Fellow with the Council of Scientific and Industrial Research, a Govt of India–sponsored Research Institute. Upon completion of her Ph.D., Dr. Gandhi joined the Anand Pharmacy College as Assistant Professor in 1999, and was subsequently promoted to the post of Professor & Head of the Institute. Dr. Gandhi has, till date, mentored over 60 Post–graduate students and 6 Doctoral Fellows. She has published more than 78 research papers in International and National Journals covering various aspects of Pharmaceutical Sciences.

Topic: Role of CYP450 Inhibitor as Cardioprotector in Myocardial Infarction
Myocardial infarction is the leading cause of morbidity and mortality world over. ROS have been recognised to cause oxidative protein modification and to act as the major mediator of ischemia⁄reperfusion injury. Increasing evidence indicates that CytochromeP450 (CYPs) have the ability to produce ROS such as, superoxide anion (O2.–), hydrogen peroxide and hydroxyl radicals. CYP2C9 mediated generation of ROS in arteries reacts with NO to produced ONOO–, thereby decreasing NO bioavailability which leads to vasoconstriction and vascular dysfunction. CYP2C6 in rat is counterpart of human CYP2C9 enzyme. Fenofibrate is inhibitor of CYP2C9. In this study, cardioprotective effect of CYP450 inhibitor against experimentally induced myocardial infarction in rats was evaluated. Coronary Artery Ligation (CAL) surgery (ligation of the left anterior descending branch of the coronary artery) and Isoproterenol (ISO) induced Myocardial Infarction [by administration of first dose of ISO (85 mg⁄ kg, S.C) on 27thday of study followed by second dose of ISO after 24 hours) models were used to study the effect of Fenofibrate (FF) at two dose level, 100mg/kg, 150 mg/kg, administered i.p. on the day of surgey in the CAL model and once a day p.o. for 28 days in ISO model in Male Wistar Albino rats (250±35 gm). Sulphafenazole (90 µg/kg) and Nebivolol (5mg⁄kg) were used as standard drugs. After the completion of the study period, serum and heart samples were collected from all experimental animals. Heart was rinsed with ice-chilled saline and weighed. Both serum and heart was then used for the estimation of various biochemical parameters like creatinine kinase–MB (CKMB), lactate dehydrogenase (LDH), hydroxy butyric dehydrogenase (α–HBDH), CYP2C6concenteration, assay of Na++⁄K+ATPase, Ca++ATPase, Mg++ATPase, estimation of Na++, K+ and Ca+, reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), catalase levels (CAT), blood Pressure (BP), heart rate (HR) & electrocardiogram (ECG). Results demonstrated that FF significantly prevented the CAL and ISO induced changes in CKMB, LDH, a-HBDH, CYP2C6 concentration, assay of Na++⁄K+ATPase, Ca++ATPase, Mg++ATPase, estimation of Na++, K+ and Ca++, GSH, SOD, MDA, CAT, BP,HR & ECG. Histopathological observations were also favourable. Thus, Fenofibrate shows potential effect on restoration of antioxidants levels and can hence be used as cardioprotective agent in myocardial infarction.

Prof. Sajal Chakraborti, PhD, DSc
Professor Dept. Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia, West Bengal


Dr. Sajal Chakraborti, PhD, DSc is a Senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases and different signal transducers in regulating pulmonary vascular tone under oxidant and calcium signaling phenomena caused by the vasoactive mediators such as thromboxane A2, endothelin–1, leukotriene D4 and angiotensin II. He has been engaged in teaching and research in Biochemistry for the past 35 years. He has undertaken 24 extramural research projects and guided 12 PhD students so far. He published ten review articles, eight chapters in different books, more than 80 original research articles and edited two books with Prof. N.S.Dhalla on Proteases: (i) Proteases in Health and Disease; and (ii) Role of Proteases in Cellular Dysfunctions.

Title: Cross–talk between PKCa–p38MAPK axis and Gi in peroxynitrite–mediated inhibition of β–adrenergic response in pulmonary artery smooth muscle cells.
In the context of cross–talk between transmembrane signaling pathways, we studied the loci within the β–adrenergic receptor–G protein–adenyl cyclase system at which PKC exerts regulatory effects of peroxynitrite (ONOO–) on isoproterenol stimulated adenyl cyclase activity and cAMP production in pulmonary artery smooth muscle cells. Treatment of the cells with ONOO– stimulated PKCa activity and that subsequently increased p38MAPK phosphorylation. Pretreatment with Go6976 (PKCa inhibitor) and SB203580 (p38MAPK inhibitor) eliminated ONOO– caused inhibition on isoproterenol stimulated adenyl cyclase activity. Pretreatment with Go6976, but not SB203580, prevented ONOO– induced increase in PKC-a activity. This inhibitory effect of ONOO– was eliminated upon pretreatment of the cells with pertussis toxin thereby pointing to a Gi dependent mechanism. This hypothesis was reinforced by Gia phosphorylation as well as by the observation of the loss of the ability of Gpp(NH)p (a mesure of Gi–mediated response) to stimulate adenyl cyclase activity upon ONOO- treatment to the cells. We suggest the existence of a pertussis toxin sensitive G protein (Gi)–mediated mechanism in isoproterenol stimulated adenyl cyclase activity, which is regulated by PKCa- p38MAPK axis dependent phosphorylation of Gia in pulmonary artery smooth muscle cells.

CPR 10 success stories

1. Hands–only CPR 10 English

2. Hands–only CPR 10 (Hindi)

3. Ms Geetanjali, SD Public School Successful Story

4. Success story Ms Sudha Malik

5. BVN School girl Harshita does successful hands–only CPR 10

6. Elderly man saved by Anuja

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Rabies News (Dr. A K Gupta)

What are most dangerous sites of bites/exposure in man?

Theoretically, the richly innervated areas like head, neck, face, hands and genitals are the most dangerous sites of bite in man. But practically, it is often the wounds on legs, which are ignored/neglected, that cause rabies.

cardiology news

Elderly Beware of Commonly Prescribed Group of Drugs

Anti–cholinergics, a commonly prescribed group of drugs, may cause elderly people to "slow down" in their daily physical activities.

Two reports from Wake Forest University School of Medicine support findings that anti–cholinergic drugs – Used to treat acid reflux, Parkinson’s disease and urinary incontinence –– may cause older people to lose their thinking skills more quickly than those who do not take the medicines.

Anti–cholinergic drugs work by blocking acetylcholine, a chemical that enhances communication between nerve cells in the brain, from binding to its receptors in nerve cells.

Older adults taking anti–cholinergics become more likely to walk more slowly and to need help in other daily activities. These results are true even in older adults who have normal memory and thinking abilities.

For older adults taking a moderately anticholinergic medication, or two or more mildly anticholinergic medications, their function is similar to that of someone three to four years older.

Common anticholinergic medicines include blood pressure medication, nifedipine; the stomach antacid, ranitidine, and the incontinence medication, tolterodine.

Cholinesterase inhibitors, a family of drugs used to treat dementia by increasing levels of acetylcholine include donepezil, galantamine, rivastigmine and tacrine. About 10 percent of patients may be taking tolterodine and dozepezil together. The two drugs are pharmacological opposites, which led to the hypothesis that the simultaneous treatment of dementia and incontinence could lead to reduced effectiveness of one or both drugs.

cardiology news

(Dr KK Aggarwal, Group Editor in Chief, IJCP Group of Publications and eMedinewS)

  • New guidance from the American Heart Association⁄American Stroke Association focuses on stroke prevention specifically in women, who have a risk profile that differs from that of men. Many stroke risk factors are shared by both men and women, so the new document zeroes in on those that are unique to women, including issues surrounding pregnancy, oral contraceptive use, and postmenopausal hormone use, and those that have a greater impact in women, including migraine with aura, diabetes, hypertension, obesity, metabolic syndrome, and atrial fibrillation. The new AHA⁄ACC guidance was written by a group chaired by Cheryl Bushnell, MD, MHS, of Wake Forest Baptist Medical Center in Winston–Salem, N.C., and published online in Stroke: Journal of the American Heart Association.
cardiology news

(Dr KK Aggarwal, Group Editor in Chief, IJCP Group of Publications and eMedinewS)

  • The American Heart Association recommends that everyone keep sodium intake to less than 1,500 mg per day, but 90 percent of children exceed that amount. According to a new study in Pediatrics 2014, teenagers who eat a high–sodium diet tend to be heavier and have more body fat than those who eat less salt. Researchers found that was the case regardless of how much total food teenagers ate or how often they drank sugary beverages.
  • The first long–term outcome study of low–grade gliomas in children shows that 87% of patients are still alive 20 years after their diagnosis, but that outcomes are significantly inferior in those treated with radiation therapy. The study was published online January 30 in Pediatric Blood & Cancer.
cardiology news

Total CPR since 1st November 2012 – 86664 trained

Media advocacy through Web Media

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press release

Every arthritis is not same

Every arthritis is not the same. While osteoarthritis also called as green arthritis may require only painkillers and rehabilitation exercises, the red inflammation arthritis called rheumatoid arthritis if not treated aggressively and early can end up with serious deforming complications, said Padma Shri & Dr. B C Roy National Awardee, Dr. K K Aggarwal, President Heart Care Foundation of India and Senior National Vice President, Indian Medical Association.

Any arthritis in young women of child–bearing age should not be ignored, especially if it is worse in the morning and improves by movement. Most of them will have high platelet count on blood examination.

These patients require aggressive treatment with disease-modifying drugs within days of the onset of symptoms and diagnosis. Approximately 1–2% of population may have this type of disease.

Osteoarthritis, on the other hand, is a disease of age 50+ and is due to wear and tear of various joints in the body and break down of the cartilage cushion in the joints. It mainly affects the weight-bearing joints like the knees, hips, neck and lower back joints. Inflammation is not a major feature of osteoarthritis. The experts said that another form of joint disorder is due to gout which is never seen in people below 40 years of age and is almost never seen in young women before the onset of menopause unless there is a known underlying kidney disease and never seen in children.

The progression of osteoarthritis can be arrested with appropriate exercises, weight reduction and preventing posture and movement that worsen the disease.

Typical wear and tear of osteoarthritis is caused by sitting cross legged, doing padmasana, squatting, other non physiological postures, sitting on low level surface like floor and low chairs, doing push ups, going up and down on stairs, etc.

Most yoga postures should be done under medical supervision and should follow with a counter yoga exercise.

Most patients of serious arthritis end up with treatment with other systems of medicines or with quacks.

About HCFI : The only National Not for profit NGO, on whose mega community health education events, Govt. of India has released two National Commemorative stamps and one cancellation stamp, and who has conducted one to one training on" Hands only CPR" of 86664 people since 1st November 2012.

The CPR 10 Mantra is – "Within 10 minutes of death, earlier the better; at least for the next 10 minutes, longer the better; compress the centre of the chest of the dead person continuously and effectively with a speed of 10×10 i.e. 100 per minute."

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CPR Training, Chinmaya Vidyalaya at Vasant Vihar, Delhi 4th February 2014

press release

Treating vitamin D deficiency in the country

vedio of day

today video of the dayPadma Shri & Dr B C Roy National Awardee, Dr KK Aggarwal on Tackling tension headaches

Hands only CPR 10 Utsav, 15th December 2013

Dr KK Aggarwal receives Harpal S Buttar Oration Award from Nobel Laureate Dr Ferid Murad

eMedi Quiz

High resolution computed tomography of the chest is the ideal modality for evaluating:

1. Pleural effusion.
2. Interstitial lung disease.
3. Lung mass.
4. Mediastinal adenopathy.

Yesterday’s Mind Teaser: Presence of food might be expected to interfere with drug absorption by slowing gastric emptying, or by altering the degree of ionisation of the drug in the stomach. Which of the following statements is not a correct example?

1. Absorption of digoxin is delayed by the presence of food.
2. Concurrent food intake may severely reduce the rate of absorption of phenytoin.
3. Presence of food enhances the absorption of hydrochlorothiazide.
4. Anitimalarial drug halofantrine is more extensively absorbed if taken with food.

Answer for yesterday’s Mind Teaser: 3. Presence of food enhances the absorption of hydrochlorothiazide.

Correct answers received from: Dr Jella, Dr Jainendra Upadhyay, Muthumperumal Thirumalpillai, Dr Chandresh Jardosh, Sangeetha Raja, Dr Avtar Krishan.

Answer for 6th February Mind Teaser: 4.Phenobarbitone with a pKa of 7.2 is largely ionized at acid pH and will be about 40% non–ionised in plasma.

Correct answers received from: Sangeetha Raja, Raju Kuppusamy.

Send your answer to ijcp12@gmail.com

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medicolegal update

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medicolegal update
medicolegal update

Masterpiece

One day a girl came home crying to her mom. The mom asked what was wrong.
The girl responded, "I’m not a creation, God made men first! I’m nothing!"
Then the mom said, "Oh baby that’s not true, God may have made men first, but there’s always a rough draft before the masterpiece."

medicolegal update

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medicolegal updatemedicolegal update

medicolegal update

Situation: A patient with renal failure came to a doctor.
Reaction: Oh, my God! Why was he given painkillers?
Lesson: Make sure to avoid painkillers in renal failure as most painkillers (barring nimesulide, paracetamol) are not kidney-friendly drugs.

medicolegal update

Ability is what you’re capable of doing. Motivation determines what you do. Attitude determines how well you do it. Lou Holtz

medicolegal update

Dr KK Aggarwal: First BP should be checked at age three http://bit.ly/15QdVeB #Health
Dr Deepak Chopra: Dealing with stress in a better way is the key to breaking the cycle of stress eating. http://bit.ly/WAYHF_DC #WAYHF

Forthcoming events

Date: Saturday 2PM-Sunday 3PM, 26–27 April 2014
Venue: Om Shanti Retreat Centre, Bhora Kalan, Pataudi Road, Manesar
Course Directors: Padma Shri and Dr B C Roy National Awardee Dr K K Aggarwal and BK Sapna
Organisers: Heart Care Foundation of India. Prajapati Brahma Kumari Ishwariye Vidyalaya and eMedinews
Facilities: Lodging and boarding provided (one room per family or one room for two persons). Limited rooms for first three hundred registrants.
Course: Meditation, Lectures, Practical workshops
Atmosphere: Silence, Nature, Pyramid Meditation, Night Walk
Registration: SMS– Vandana Rawat – 9958771177, rawat.vandana89@gmail.com
SMS – BK Sapna 9650692204, bksapna@hotmail.com

Note: Donation in Favor of Om Shanti Retreat Centre will be welcomed

medicolegal update
  1. Sir,congrats for getting DST award, wish u get many more such awards. Usha Ghera

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Dr Veena Aggarwal, Dr Arpan Gandhi, Dr Aru Handa, Dr Ashish Verma, Dr A K Gupta, Dr Brahm Vasudev, Dr GM Singh, Dr Jitendra Ingole, Dr Kaberi Banerjee (banerjee.kaberi@gmail.com), Dr Monica Vasudev, Dr MC Gupta, Dr Neelam Mohan (drneelam@yahoo.com), Dr Navin Dang, Dr Pawan Gupta(drpawangupta2006@yahoo.com), Dr Parveen Bhatia, (bhatiaglobal@gmail.com), Dr Prabha Sanghi, Dr Prachi Garg, Rajat Bhatnagar (http://www.isfdistribution.com), Dr. Rajiv Parakh, Dr Sudhir Gupta, Prof.(Dr).C V Raghuveer

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