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Editor-in-Chief eMediNexus – Dr KK Aggarwal
7th August 2018
‘Kick & Kill": Looking to cure HIV

Dr KK Aggarwal, Recipient of Padma Shri

Ever since the Human Immunodeficiency Virus (HIV) was discovered and identified as the cause of AIDS, scientists have been on the hunt for a cure, which is proving to be elusive.

The HIV virus remains concealed in the reservoir cells; for this reason, the HIV infection, which is in remission with antiretroviral drugs (ART), becomes active again as soon as ART is discontinued. Killing these latent reservoirs is therefore essential to achieving cure. Scientists are better equipped today, both with knowledge and technology, which raises hopes of finding a cure.

One among the curative strategies, which has been explored the most, is the ‘kick and kill" strategy. It is based on the premise that “kicking” (reactivating) the latent reservoirs would make the hidden HIV visible to the immune system, which then "kills" (destroys) the reactivated virus and thus eliminates the latent reservoir. However, the results of trials using the kick and kill strategy have not been very encouraging. more

Top News

Govt. plans to create around 10,000 new jobs under National Health Protection Scheme

At least 10,000 new jobs will be created with the implementation of the Centre's ambitious Ayushman Bharat-National Health Protection Mission (AB-NHPM), which aims to provide a cover of Rs 5 lakh per family annually to 10 crore poor families, according to a government official, reports ET Healthworld..... read more

Morning Medtalks

Morning MEDTalks with Dr KK Aggarwal 7th August 2018

Reversal of diabetes A clinical trial recently showed that nearly half of individuals with type 2 diabetes achieved remission to a non-diabetic state after a weight-loss intervention delivered within 6 years of diagnosis. Now a study published August 2nd in the journal Cell Metabolism reveals that this successful response to weight loss is associated with the early and sustained improvement in the functioning of pancreatic beta cells. This finding challenges the previous paradigm that beta-cell function is irreversibly lost in patients with type 2 diabetes.... read more

Practice Updates

Bone mineral density declines early in men with type 1 diabetes

Bone mineral density (BMD) declines early in the course of type 1 diabetes in men but is little affected by the condition in women, according to results of a 10-year prospective study of bone mineral density and bone turnover in males and females with type 1 diabetes published July 18, ... read more

Parents endanger their children with risky driving habits

Parents, who talk or text on mobile phones while driving with their children aged 4-10 years in the car are also more likely to engage in other risky driving behaviors, including not wearing a seat belt or driving under the influence of alcohol, whether or not children were present in the car,... read more

AKI before pregnancy increases risk of pregnancy complications despite clinical recovery

An episode of acute kidney injury (AKI) before conception is a risk factor for pregnancy complications including preeclampsia regardless of clinical recovery. The study published in the August 2018 issue of the journal Hypertension also found that the severity of AKI and shorter ... read more

Prehospital administration of plasma in post-trauma patients increases mortality risk

Mortality at 30 days in patients who had post-trauma hypotension and received standard crystalloid-based resuscitation was 33% compared with 23% in patients who received fresh frozen plasma in addition to standard resuscitation measures as demonstrated in a study ... read more

IBD patients with raised GGT should be screened for primary sclerosing cholangitis

In a study published July 31, 2018 in Digestive and Liver Disease, primary sclerosing cholangitis (PSC) was detected on magnetic resonance cholangiography (MRC) in one tenth of patients with inflammatory bowel disease who also showed abnormal LFTs. The study further recommends ... read more

eMedi Humor
Medicolegal Corner
eMedi Quiz
1. IBD
2. Cryptosporidiosis
3. Tuberculosis
4. Lymphoma
5. Lymphogranuloma venereum colitis
6. Bacterial gastroenteritis
Lifestyle Updates
Inspirational Story 1: Just listen
Inspirational Story 2: A little monkey and man
Infants born to mothers with Polycystic Ovary Syndrome (PCOS) at risk for autism
About 1 in 5 women in India affected by this condition
New Delhi, 06 August 2018: Children born to women with polycystic ovary syndrome (PCOS) may be more likely to develop autism, according to a study. Higher-than-usual levels of testosterone in the mother, as is the case in women with PCOS, can result in some of the hormone crossing the placenta during pregnancy. This can expose the unborn baby to more of this hormone, and changing its brain development, as per the findings.

About 1 in 5 women in India are affected by PCOS, a condition which affects the hormone levels. It can cause infrequent or prolonged menstrual periods or increase in male hormones (androgen). The ovaries may also develop numerous small collections of fluid (follicles) and fail to regularly release eggs.

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