All patients with MSI tumors should be tested for Lynch syndrome
Findings of a study presented June 4, 2018 at the American Society of Clinical Oncology (ASCO) 2018, which concludes today indicate that microsatellite unstable (MSI-H) and/or DNA mismatch repair deficient (MMR-D) tumors, regardless of cancer type or family history, should prompt germline testing for the evaluation of Lynch syndrome.
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Donor artery stenosis influences coronary collateral flow in low diastolic BP in T2D CTO patients
Donor artery stenosis confers greater risk for reduced coronary collateral flow when diastolic BP is decreased in type 2 diabetes (T2D) patients with chronic total occlusion (CTO). Even a moderate stenosis in the predominant collateral donor artery may be associated with lower collateral flow as diastolic BP decreases below 80 mmHg in type 2 diabetic than in non-diabetic patient..... read more
Lyon Consensus diagnostic parameters for GERD
Experts at the Lyon gastroesophageal reflux disease (GERD) consensus meeting have defined diagnostic criteria for GERD, which have been published online May 16, 2018 in Gut journal Gut. Conclusive evidence for reflux on esophageal testing include advanced grade erosive esophagitis (LA grades C and D), long-segment Barrett’s mucosa or peptic strictures on endoscopy or distal... read more
Low serum free thyroxine level affects lipid profile in depressive patients with suicidal behavior
Levels of serum total cholesterol, triglycerides and free thyroxine (FT4) in suicidal patients were greatly decreased compared with patients without suicidal behavior. These findings published May 24, 2018 in the journal Psychiatry Research suggest that low serum FT4 level affects lipid profile in major depressive patients with suicidal attempt.
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Brexipiprazole for schizophrenia approved in Europe
The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended granting marketing authorization for brexipiprazole (Rxulti, Otsuka Pharmaceutical Europe Ltd) for the treatment of schizophrenia. Brexipiprazole is atypical antipsychotic..... read more
Young males with IBD at risk of herpes zoster
A study of patients with inflammatory bowel disease (IBD) published online May 29, 2018 in Clinical Gastroenterology and Hepatology suggests that patients who are male, younger, or have Crohn's disease are at risk of herpes zoster. Use of steroids increases the risk of herpes zoster in these patients.... read more