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5th November, 2017
Autophagy and Diabetes
Dr KK Aggarwal
Autophagy in diabetes has recently been the focus of research and accumulating evidence has suggested a pathophysiological role for autophagy in diabetes.1 The word autophagy means “self eating” as it is derived from two Greek words “auto” meaning “self”, and “phagein” meaning “to eat”.
Autophagy is a catabolic process by which cells adapt to stress and starvation. It maintains cellular homeostasis by lysosomal-mediated degradation and recycling of damaged proteins and organelles such as mitochondria. 2,3 Three types of autophagy are described: Macroautophagy, microautophagy and chaperone-mediated autophagy. The most prevalent of these is macroautophagy.4
Hyperglycemia secondary to insulin resistance is implicated in the pathogenesis of diabetes. In the natural history of type 2 diabetes, hypertrophy of the pancreatic β-cells occurs to compensate for hyperglycemia and insulin resistance occurs early in the disease. As the disease progresses, dysfunction and loss of β-cells occur. 1
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Top News
Practice Updates
eMedi Humor
Medicolegal Corner
eMedi Quiz
1. Give antibiotics to all other patients in the ward.
2. Fumigate the ward.
3. Disinfect the ward with sodium hypochlorite.
4. Practice proper hand washing.
Lifestyle Updates
Inspirational Story 1: : Planting Potatoes
Inspirational Story 2: Promise Yourself
Air pollution at an all-time high in Delhi
IMA strictly advises against exercising outdoors in the morning among other things
New Delhi, 04 November 2017: As per a recent study, air pollution has led to five lakh premature deaths across India. The weather conditions in the national capital are rapidly deteriorating and there is only one advise for those going for an early morning walk or run --- stay indoors. The reason is that air pollution is at an all-time high and the morning air can have drastic repercussions on one’s health. As per the IMA, exposure to this toxic air can affect the lungs, blood, vascular system, brain, heart, and even the reproduction system.
Concentration of PM 2.5 can cause tiny, hazardous particles to enter the lungs. This in turn can cause problems such as chronic obstructive pulmonary disorder and also impact lung functioning. The IMA has also advised strongly against running a marathon in this condition, as doing so can deposit about two tablespoons of toxic ash in the lungs.
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