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Editorial (Dr SS Agarwal, Dr K K Aggarwal)
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4th  October 2016
'Three-parent' DNA baby: A revolutionary technique or the answer?
 
Mitochondrial diseases are caused by pathogenic mutations in the mitochondrial DNA or mutations in nuclear DNA involved in mitochondrial function and inherited only from the mother. They are debilitating and potentially fatal diseases involving multiple organ systems and cannot be diagnosed prenatally.  And like autism, muscular dystrophy, chronic fatigue syndrome, they present predominantly with neurolgic and myopathic features. Several such diagnoses are usually investigated for first making it a difficult condition to diagnose and a very high index of clinical suspicion is required to even consider this diagnosis.
 
A diagnosis of mitochondrial disease spells doom for the patient and fills the doctor with hopelessness as there is no cure for mitochondrial diseases, that is, until now.
 
Recently, New Scientist magazine reported the ground-breaking story of a 5-month-old boy, who is the first baby in the world to be born to a couple from Jordan using ‘three-parent technique’ that incorporates DNA from three people; the biological parents and an unknown female donor. The baby has nuclear DNA from his mother and father, and mitochondrial DNA from an unknown female donor, the "second" healthy mother.
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a. Avoiding suctioning unless cyanosis occurs 
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If a victim collapses due to a Sudden Cardiac Arrest - do not wait for the doctor to arrive
 
A cardiac arrest is a condition when the heart stops working. However, the brain stays alive for up to ten minutes making it possible to revive the victim's heart through hands only CPR
 
New Delhi October 3rd, 2016: Imagine a case where a person collapses in front of you due to a sudden cardiac arrest and upon checking you find that his or her heart has stopped beating. What would your immediate reaction be- would you wait for an ambulance to arrive or would you do something to revive them? In such situations, every minute counts and can reduce the chances of a person’s survival by up to 10%. 
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