Multistate Outbreak of Salmonella Infections Linked to Hedgehogs
A CDC investigation update of a multistate outbreak of Salmonella infections linked to contact with pet hedgehogs has been posted at https://www.cdc.gov/salmonella/typhimurium-01-19/index.html.
The update states that 10 more people infected with the outbreak strain of Salmonella have been reported, bringing the total to 27 people. Two people have been hospitalized and no deaths have been reported. Forty-two percent of the ill people are children age 12 or younger
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Oxford Health NHS Foundation Trust in no confidence vote
A vote of no confidence in health bosses has been declared after the temporary closure of a hospital ward.
The 12 beds of Oxford Community Hospital shut because there were not enough nurses. Oxford Health NHS Foundation Trust said every effort would be made to reopen the beds. But Oxfordshire's Health Overview and Scrutiny Committee (HOSC) criticized the trust for what it said was a lack of communication.
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Depression may put women at risk of chronic diseases
Women who experience symptoms of depression, even without a clinical diagnosis, are at an increased risk of developing multiple chronic diseases, according to a study.
The study, published in the journal Health Psychology, examined 7,407 middle-aged women (45-50 years) for over 20 years. During the study period, 43.2 per cent women experienced elevated symptoms of depression and just under half the cohort were diagnosed or took treatment for depression.... read more
Methylphenidate Dose Titration in ADHD Should Be Based on Outcomes
Dose titration of methylphenidate in patients with attention-deficit/hyperactivity disorder (ADHD) should aim to maximize the ratio of benefit to adverse effects, as there appears to be no scientific rationale for published maximum doses, according to a meta-analysis.
Various guidelines recommend titrating the dose of methylphenidate for maximal benefit with minimal adverse effects, and they usually specify approved dose ranges in the interests of safety. ... read more
US Drug Prices Rise in 'Highly Synchronized' Pattern, Study Finds
The costs for certain widely used medicines continue to rise in the United States even amid competition from similar products, according to a new study. The results run contrary to normal expectations about market forces on prices.
"That was one of the more disheartening findings" of the study, lead author Nathan E. Wineinger, PhD, from Scripps Research in La Jolla, California, said. In an article published in JAMA Network Open, Wineinger and his coauthors said they found ... read more
Immunotherapy Combo Boosts Response in Bladder Cancer
Dual checkpoint-inhibitor therapy showed greater activity against advanced or metastatic urothelial cancer but imposed more toxicity than a single agent, a preliminary clinical evaluation revealed.
Pairing a lower dose of anti-PD-1 agent nivolumab (Opdivo) with a higher dose of the CTLA-4 inhibitor ipilimumab... read more