Editor-in-Chief eMediNexus – Dr KK Aggarwal
29th July 2019

FDA approves Boxed Warning about increased risk of thrombosis with higher dose of tofacitinib used for ulcerative colitis

Dr KK Aggarwal, Recipient of Padma Shri

(Excerpts from US FDA): In an update to its Drug Safety Communication issued on February 25, the US FDA has approved new warnings about an increased risk of thrombosis (blood clots) and of death with the 10 mg twice daily dose of tofacitinib, which is used in patients with ulcerative colitis. Tofacitinib 10 mg twice daily is not approved or recommended for the treatment of rheumatoid arthritis or psoriatic arthritis.

The FDA has issued the following safety information:...read more

Post-kala-azar dermal leishmaniasis patients are potentially infectious

Dr KK Aggarwal, Recipient of Padma Shri

Patients who have been successfully cured of visceral leishmaniasis can continue to infect hundreds of people for years, if they develop a skin condition known as post-kala-azar dermal leishmaniasis (PKDL).

In the largest study to date of patients with PKDL published in July 2019 issue of the journal Clinical Infectious Diseases, researchers found that 60% of people with the skin condition passed the leishmaniasis parasite on to sandflies. This means the insects could then go on to infect more people with the potentially deadly disease....read more

Practice Updates

HC junks plea to legalize cannabis

New Delhi: Delhi High Court on Friday dismissed with a cost of Rs 10,000 a petition seeking to legalize cannabis for medical purposes. Cannabis is a banned drug whose possession or use attracts criminal prosecution. A bench of Chief Justice D N Patel and Justice C Hari Shankar said there was no substance in the petition and it was not inclined to grant the prayer.... read more

Statement on governance and oversight of human genome editing

The WHO expert advisory committee on governance and oversight of human genome editing convened on March 18-19, 2019. At this meeting the Committee in an interim recommendation to the WHO Director-general stated that “it would be irresponsible at this time for anyone to proceed with clinical applications of human germline genome editing.”... read more

Mediterranean diet during pregnancy may lower gestational diabetes risk, finds study

Women who follow a Mediterranean-style diet during pregnancy, including a daily portion of walnuts and almonds, and extra virgin olive oil, may have a lower risk of gestational diabetes, a study claims. The results, published in the journal PLOS Medicine, found women who followed a Mediterranean-style diet during pregnancy had a 35% lower risk of gestational diabetes and on average gained 2.75 pounds less,... read more

Two-Drug HIV Treatment Holds Up at 96 Weeks

HIV treatment with a two-drug regimen remained non-inferior to three-drug therapy among treatment-naive patients at 96 weeks, with no cases of treatment-emergent resistance, reported new research. Pooled data from the phase III GEMINI 1 and 2 trials at 96 weeks showed that 86% of patients in the dolutegravir plus lamivudine (Dovato) arm had HIV RNA ... read more

Starting Dialysis at Higher eGFR in Kids Linked to Worse Survival

Starting dialysis in children with higher estimated glomerular filtration rate (eGFR) is associated with worse survival, according to a retrospective study of pediatric patients registered in the U.S. Renal Data System (USRDS). Overall, 29% of the children had higher eGFR at dialysis initiation, the researchers report in the Journal of the American Society of Nephrology.... read more

FMT Tx Disappoints in Diarrhea-Predominant IBS

A microbiome makeover with fecal microbiota transplantation (FMT) proved no better -- and perhaps somewhat worse -- than placebo for easing the symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D), researchers reported. In the double-blind, randomized, placebo-controlled crossover trial, primary endpoint, IBS-Symptom Severity Scores (IBS-SSS), did not differ between FMT recipients and placebo recipients at 12 weeks ... read more

Spinal Stimulation May be Best 'Medicine' for Intractable Spine, Limb Pain

In patients with intractable spine and limb pain, spinal stimulation (SS), particularly with newer technologies, was associated with better pain relief than medical therapy, a systematic review and meta-analysis reveals. As reported online July 3 in Mayo Clinic Proceedings, 12 trials involving 980 patients were included. Compared with medical therapy,... read more

IDEJ Update

Indian Diabetes Educator Journal (IDEJ), 1st of its kind in India aims to keep the members of diabetes care team abreast with concepts of DSME (Diabetes self-management education) and DSMS (Diabetes self-management support). IDEJ has set a new benchmark in educating the diabetes educators about evolving the concept of DSME- reaching to more than 25000 through Digital and Print Medium..... read more

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