![]() | ||
---|---|---|
Head Office: 39 Daryacha, Hauz Khas Village, New Delhi, India. e-Mail: drkk@ijcp.com, Website: www.ijcpgroup.com | ||
FIRST NATIONAL DAILY eMEDICAL NEWSPAPER OF INDIA | ||
emedinews is now available online on www.emedinews.in or www.emedinews.org | ||
| ||
Dear Colleague, 22nd January, Friday, 2010 New treatment for refractory ascites In patients with cirrhosis, ascites is defined as refractory when it cannot be mobilized or recurs early in standard diuretic therapy. A randomized controlled trial has shown a beneficial effect from infusion of small volume hypertonic saline plus high dose furosemide in patients with refractory ascites. A study, published in the May 2009 edition of Aliment Pharmacol Ther, compared the safety and efficacy of intravenous high dose furosemide + hypertonic saline solutions (HSS) to repeated paracentesis in patients with cirrhosis and refractory ascites. Eighty-four subjects (59/25 M/F) with cirrhosis, admitted for refractory ascites were randomly assigned to receive furosemide (250-1000 mg/bid IV.) plus HSS (150 ml H(2)O with NaCl 1.4-4.6% or 239-187 mEq/L) (60 patients, group A) or to repeated paracentesis and a standard diuretic schedule (24 patients, group B).During hospitalization group A patients had more diuresis (1605 ± 131 mL vs 532 ± 124 mL than group B patients; p<0.001) and a greater loss of weight at discharge (-8.8 ± 4.8 kg vs -4.5 ± 3.8 Kg, p<0.00). Control of ascites, pleural effusions and/or leg edema was deemed significantly better in Group A. This randomized pilot study suggests that HHS plus high dose furosemide is a safe and effective alternative to repeated paracentesis when treating hospitalized patients with cirrhosis and refractory ascites. Dr KK Aggarwal | ||
Question Of the day Dr Good Dr Bad Make Sure Formulae in Imaging Mistakes in Clinical Practice ENT Facts Emedinews Try this It Works Milestones in Neurology Laughter the Best Medicine Quote SMS Anemia Medifinance Medilaw
Emedinews calculator Presswatch (Dr Vivek Chhabra) Letter to the editor | ||
(Advertorial section) ZEN IMMUNE -FACT SHEET Advertising in emedinews emedinews is the first daily emedical newspaper of the country. One can advertise with a singe insertion or 30 insertions in a month. Contact: drkk@ijcp.com. emedinews@gmail.com emedinews-revisiting 2010 The second emedinews-revisiting 2010 conference will be held at MAMC on 2nd January 2011. The event will have a day long CME, doctor of the year awards, cultural hangama and live webcast. Suggestions are invited. Also if you like emedinews you can FORWARD it to your colleagues and friends. Please send us a copy of your forwards. |