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Editor-in-Chief eMediNexus – Dr KK Aggarwal
21st August 2018
A three-drug combo pill lowers BP more than usual care

Dr KK Aggarwal, Recipient of Padma Shri

A new low-dose antihypertensive combination drug, containing medications belonging to different class, may have the potential to revolutionize treatment of hypertension globally. This ‘triple pill’ contains three antihypertensive drugs: Telmisartan (20 mg), amlodipine (2.5 mg) and chlorthalidone (12.5 mg).

A randomized clinical trial, the TRIUMPH trial, which was conducted in Sri Lanka compared once-daily low-dose triple antihypertensive combination drug with usual care in 700 patients with with mild to moderate hypertension, who needed either initiation (untreated patients) or escalation (patients on monotherapy) of antihypertensive therapy. In usual care, patients received their doctor's choice of blood pressure-lowering medication.

Among 700 randomized patients (mean age, 56 years; 58% women; 29% had diabetes; mean baseline systolic/diastolic BP, 154/90 mm Hg), 675 (96%) completed the more

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Top News

Children at risk in DRC Ebola outbreak, says UNICEF

Children represent an unusually high proportion of people affected by the ongoing Ebola outbreak in the eastern Democratic Republic of the Congo (DRC), UNICEF said. Two children have already died from the disease. The Ebola treatment centres in Beni and Mangina are currently treating six children that are infected by the disease or suspected to be. UNICEF has identified 53 orphaned children who have lost their parents to Ebola.... read more

Morning Medtalks

Morning MEDTalks with Dr KK Aggarwal 21st August 2018

IRDAI asks insurance companies to also cover mental illness in insurance policies·
Insurance Regulatory and Development Authority of India (IRDAI) has directed all the insurance companies to make a provision to cover mental illness also in insurance policies.

"Reference is drawn to the Mental Healthcare Act, 2O17 which has come into force w.e.f 29.5.2018. As per Sec 21(4) of the said Act, every insurer shall make provision for medical insurance for treatment of mental illness on the same basis as is available for treatment of physical illness.... read more

Practice Updates

Study identifies new predisposition genes for breast and ovarian cancer

A study published online August 16, 2018 in JAMA Oncology has identified MSH6 and ATM as possible moderate-risk breast and ovarian cancer predisposition genes, respectively in addition to confirming several well-known breast or ovarian cancer gene associations. In the study, an increased risk of breast cancer was associated with PALB2, ATM, CHEK2, and MSH6 genes,.. read more

"The Power of Play", a new AAP clinical report recommends play for healthy and creative children

A new clinical report from the American Academy of Pediatrics (AAP) titled "The Power of Play: A Pediatric Role in Enhancing Development in Young Children” recommends play for children to buffer toxic stress, build parental relationships and improve executive functioning. The most powerful way children learn is not only in classrooms or libraries but rather on playgrounds and in playrooms.... read more

Anti-reflux surgery may slow progression of idiopathic pulmonary fibrosis

Results of the WRAP-IPF trial conducted in six medical centers in the US has suggested that laparoscopic fundoplication, to treat abnormal acid gastroesophageal reflux in patients with idiopathic pulmonary fibrosis (IPF) may slow its progression. The results are published online August 9, 2018 ... read more

FDA clears peripheral nerve stimulation system for pain management

The US Food and Drug Administration (FDA) has cleared SPRINT® endura™ (single lead) and extensa™ (dual lead) Peripheral Nerve Stimulation (PNS) Systems for pain management. The SPRINT System is the first and only dual lead capable percutaneous PNS System cleared by the FDA and indicated for up to 60 days in the back and/or extremities for both chronic... read more

Risk factors within the target ranges lowers risk of death in patients with type 2 diabetes

Patients with type 2 diabetes who had all five risk-factor variables (elevated A1c, high LDL-cholesterol, albuminuria, smoking and high BP) within the target ranges appeared to have little or no excess risk of death, myocardial infarction, or stroke, as compared with the general population, according to a study published August 16, 201 in the New England Journal of Medicine... read more

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Kerala floods leave more than 300 dead and many more stranded
Vigilance and precautions are the need of the hour to prevent the aftermath of illnesses that follow floods
New Delhi, 20 August 2018: With over 250% more rain than normal between 8th and 15th August 2018, the state of Kerala is battling the worst floods in its history. More than 300 people have lost their lives and many more have been left stranded. Across the state, relief teams are running against time to ensure food and medicines reach those in need. Many have pitched in to the rescue efforts through their presence well as monetary contributions.

Flood waters not only take a toll on human life, but also cause an aftermath of illnesses. The health effects of floods are both immediate and long term. One of the most pertinent problems of flooding is the water-borne and vector-borne diseases such as malaria, dengue, leptospirosis,

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