Editor-in-Chief eMediNexus – Dr KK Aggarwal
20th May 2019
Ignore TSH up to 10

Dr KK Aggarwal, Padma Shri Awardee

An international panel of experts has concluded that patients with subclinical hypothyroidism should not be routinely offered thyroid hormone replacement therapy.

In the recommendations published online this week in the BMJ, the expert panel writes "for adults with subclinical hypothyroidism, thyroid hormones consistently demonstrate no clinically relevant benefits for quality of life or thyroid-related symptoms, including depressive symptoms, fatigue, and body mass index (BMI)."

The guidance, based on findings from a systematic review and meta-analysis of 21 trials with 2192 participants published in November (JAMA. 2018;320:1349-1359) represents a "strong recommendation” against prescribing thyroid hormones (primarily levothyroxine LT4) in adults with subclinical hypothyroidism....read more

Low LDL levels but high hsCRP increase risk of adverse cardiac events post-PCI

Dr KK Aggarwal, Padma Shri Awardee

Patients undergoing percutaneous coronary intervention (PCI), who had well-controlled LDL cholesterol (LDL-C) but persistently high levels of high-sensitivity C-reactive protein (hsCRP) were at a more than twofold greater risk for major adverse cardiac and cerebrovascular events, compared with those who had low LDL-C and low hsCRP levels.

Over a 1-year follow-up there was a stepwise increase in major adverse cardiovascular and cerebrovascular events.

Patients were categorized according to their serial hsCRP levels, with high hsCRP defined as at least 2 mg/L....read more

Video Of The Day : All about liver imaging
Practice Updates

Abortion ban: Republican State ALABAMA passes most restrictive law IN US

On Tuesday, the Alabama Senate passed the most restrictive abortion bill in the United States, which places a near-total ban on the termination of pregnancy – even in cases of rape and incest – and could punish doctors who perform the procedure with life in prison. The text passed by the Republican-led senate has been sent to Governor Kay .... read more

Final comments invited

Dear All, a reminder of the call for any final comments on the draft "Minimum Standards and Recommendations for Reproductive, Maternal, Newborn and Child Health Care" for Emergency Medical Teams.

Please use the following link:https://docs.google.com/document/d/1SkTUUKu7JL765FTU81gAxeDTIbYCpZMnHxnbzM32KE4/edit?usp=sharing .... read more

CDC's Eight Tips for Safe and Healthy Summertime Work and Play

Centers for Disease Control and Prevention has proposed health tips, alerts, and social media updates that include practical advice for travelers, swimmers, and for all those who want to beat the summer heat...... read more

Countries move towards elimination of mother-to-child transmission of HIV, syphilis, hepatitis B and Chagas disease

Countries are moving towards the elimination of mother-to-child transmission of HIV, syphilis, hepatitis B and Chagas, but progress has been uneven, suggests a new report from the Pan American Health Organization (PAHO).....read more

UN observes World Bee Day on May 20

Bees and other pollinators, such as butterflies, bats and hummingbirds, are increasingly under threat from human activities. Pollinators allow many plants, including several food crops, to reproduce. Not only do pollinators contribute directly to food security, they are key to conserving biodiversity - a pillar of the Sustainable Development Goals.....read more

EU Panel Backs Market Withdrawal of Fenspiride

The European Medicines Agency's (EMA) Pharmacovigilance Risk Assessment Committee (PRAC) has recommended canceling marketing authorizations for fenspiride medicines owing to heart risks, preventing them from being sold in the European Union (EU), according to an agency news release.....read more

CDC Guidelines Reject Annual TB Testing for Most Healthcare Workers

Healthcare workers should be tested for tuberculosis (TB) when they are hired and should be retested only after an occupational exposure, suggest new guidelines issued by the Centers for Disease Control and Prevention (CDC), published online May 17, 2019 in Morbidity and Mortality Weekly Report.....read more

IDEJ Update

Indian Diabetes Educator Journal (IDEJ), 1st of its kind in India aims to keep the members of diabetes care team abreast with concepts of DSME (Diabetes self-management education) and DSMS (Diabetes self-management support). IDEJ has set a new benchmark in educating the diabetes educators about evolving the concept of DSME- reaching to more than 25000 through Digital and Print Medium..... read more

eMedi Humor
Medicolegal Corner
eMedi Quiz
1. pKa of a drug is the pH at which the drug is 50% ionized.
2. Small changes of pH near the pKa of a weak acidic drug will not affect its degree of ionization.
3. Knowledge of pKa of a drug is useful in predicting its behavior in various body fluids.
4. Phenobarbitone with a pKa of 7.2 is largely ionized at acid pH and will be about 40% non-ionized in plasma.
Lifestyle Updates
Inspirational Story 1: A True friend
Inspirational Story 2: The Greatest Gift is Love