Informed and documented consent is a must before any off-label use of a drug
Dr KK Aggarwal, Recipient of Padma Shri
Off-label use of drugs is a common practice all over the world. Off label use means that the particular drug is used for an indication that is not otherwise approved by the regulatory authority, the Drug Controller General of India (DCGI) in our country, and is not included in the package insert. The package insert or label carries instructions about indications, contraindications and dosing and other instructions. This information is approved by the DCGI for every drug sold in India.
In the Anuradha Saha case of medical negligence, the dose of the injection depomedrol prescribed (80 mg twice daily) was much higher than the maximum recommended dose as recommended by the manufacturer. Anything, which is not as recommended by the manufacturers or is outside DCGI’s recommendations is off-label use and can be called a trial..... read more
Donors have pledged an additional US$15.3 million to support quick action by the World Health Organization to tackle disease outbreaks and humanitarian health crises through its emergency response fund in 2018, the Contingency Fund for Emergencies (CFE)..... read more
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TATT can lead to chronic fatigue syndrome over time Children and adolescents are most susceptible due to gadget use; adults under work stress can also suffer from this condition
New Delhi, 31st March 2018: About 80% of adolescents today do not get the recommended amount of sleep, as per a survey. Other than this, a significant number of them suffer from what is called the Tired All The Time (TATT) syndrome. Prolonged hours on the computer or TV are responsible for this condition and children or adolescents often complain of tiredness and fatigue.
A drained-out feeling and extreme tiredness over a relatively short period is called TATT. When it gets magnified, over a long duration, it can lead to chronic fatigue syndrome. TATT can be confusing to diagnose at times as the symptoms can mimic other conditions such as diabetes, anaemia, depression, etc.