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Editor-in-Chief eMediNexus – Dr KK Aggarwal
Editor-in-Chief eIMANews - Dr Ravi Wankhedkar
1st April 2018
Informed and documented consent is a must before any off-label use of a drug

Dr KK Aggarwal, Recipient of Padma Shri

Off-label use of drugs is a common practice all over the world. Off label use means that the particular drug is used for an indication that is not otherwise approved by the regulatory authority, the Drug Controller General of India (DCGI) in our country, and is not included in the package insert. The package insert or label carries instructions about indications, contraindications and dosing and other instructions. This information is approved by the DCGI for every drug sold in India.

In the Anuradha Saha case of medical negligence, the dose of the injection depomedrol prescribed (80 mg twice daily) was much higher than the maximum recommended dose as recommended by the manufacturer. Anything, which is not as recommended by the manufacturers or is outside DCGI’s recommendations is off-label use and can be called a trial..... read more

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Video Of The Day : Know more About Smile Train
Top News

Donors pledge over US$ 15 million to WHO’s Contingency Fund for Emergencies

Donors have pledged an additional US$15.3 million to support quick action by the World Health Organization to tackle disease outbreaks and humanitarian health crises through its emergency response fund in 2018, the Contingency Fund for Emergencies (CFE)..... read more

Morning Medtalks

Morning Medtalks with Dr KK Aggarwal 31st March 2018

1. Super-gonorrhoea, Syphilis, HIV and Mycoplasma genitalium are developing resistance to antimicrobial treatments.
2. Science Alert: It's Official: A British Man Has Contracted The First Case of Untreatable 'Super-Gonorrhea'
3. For most patients who meet criteria for zoster vaccination, give recombinant zoster vaccine (RZV) rather than the live attenuated zoster vaccine (ZVL) .... read more

Practice Updates

Study links chronic fatigue syndrome to low T3 syndrome

A study published March 20, 2018 in Frontiers in Endocrinology has shown a higher prevalence of “low T3 syndrome” or “non-thyroidal illness syndrome” in patients with chronic fatigue syndrome (CFS) with low TT3 and FT3 together with normal/high-normal FT4 and normal TSH..... read more


Higher prevalence of LV diastolic dysfunction in patients with progeria

Diastolic dysfunction was found to be the most prevalent cardiac abnormality in patients with Hutchinson-Gilford progeria syndrome appearing early in life with age-related decline, according to a study published February 21, 2018 in JAMA Cardiology..... read more


Consensus statement on identification of patients who need H. pylori testing

Eleven experts on management of adult and pediatric patients with Helicobacter pylori in the US have issued a consensus statement after their participation in the Houston Consensus Conference, which includes identification of appropriate patients for testing among other recommendations..... read more


HbA1c variability may be an indication of diabetic peripheral neuropathy in type 2 diabetes

Increased HbA1c variability is closely associated with DPN in type 2 diabetic patients and could be considered as a potent indicator for DPN in these patients, as suggested in a study published March 29, 2018 in Cardiovascular Diabetology...... read more


Low birth weight associated with future lower visual acuity

A study reported online March 15, 2018 in the British Journal of Ophthalmology says that individuals with low birth weight are more likely to have lower visual acuity and a higher myopic refractive error in adulthood...... read more

eMedi Humor
Medicolegal Corner
eMedi Quiz
a. A compartment syndrome of forearm
b. Failure to heal
c. Healing in a non anatomic position
d. Injury to the median nerve
e. Permanent restriction of the elbow motion
Lifestyle Updates
 
Inspirational Story 1: Two Types of People
Inspirational Story 1: God's embroidery
TATT can lead to chronic fatigue syndrome over time
Children and adolescents are most susceptible due to gadget use; adults under work stress can also suffer from this condition
 
New Delhi, 31st March 2018: About 80% of adolescents today do not get the recommended amount of sleep, as per a survey. Other than this, a significant number of them suffer from what is called the Tired All The Time (TATT) syndrome. Prolonged hours on the computer or TV are responsible for this condition and children or adolescents often complain of tiredness and fatigue.

A drained-out feeling and extreme tiredness over a relatively short period is called TATT. When it gets magnified, over a long duration, it can lead to chronic fatigue syndrome. TATT can be confusing to diagnose at times as the symptoms can mimic other conditions such as diabetes, anaemia, depression, etc.

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