eMedinewS17th March 2014,Monday

Dr K K AggarwalPadma Shri and Dr B C Roy National Awardee

Dr KK Aggarwal

President, Heart Care Foundation of India; Sr Consultant Physician, Cardiologist & Dean Medical Education Moolchand Medcity; Editor in Chief IJCP Group, National Vice President Elect, Indian Medical Association; Chairman Ethical Committee Delhi Medical Council, Hony. Visiting Professor (Clinical Research) DIPSAR; Chairman (Delhi Chapter) International Medical Sciences Academy (March 10–13); Hony Director IMA AKN Sinha Institute (08–09); Hony Finance Secretary National IMA (07–08); Chairman IMA Academy of Medical Specialties (06–07); President Delhi Medical Association (05–06), President IMA New Delhi Branch (94–95, 02–04);
For updates follow at
www.facebook.com/Dr KKAggarwal

Researchers find reason why many vein grafts fail

NIH intramural–led study uncovers biology behind improper graft remodeling

National Institutes of Health researchers have identified a biological pathway that contributes to the high rate of vein graft failure following bypass surgery. Using mouse models of bypass surgery, they showed that excess signaling via the Transforming Growth Factor Beta (TGF–Beta) family causes the inner walls of the vein to become too thick, slowing down or sometimes even blocking the blood flow that the graft was intended to restore. Inhibition of the TGF–B signaling pathway reduced overgrowth in the grafted veins.

The team, led by Manfred Boehm, M.D., chief of the Laboratory of Cardiovascular Regenerative Medicine at NIH’s National Heart, Lung, and Blood Institute, identified similar properties in samples of clogged human vein grafts, suggesting that select drugs might be used in reducing vein graft failure in humans.

Endothelial cells not only form the inner lining of a blood vessel, but also contribute to blood vessel narrowing as shown in this mouse vein graft model. Endothelial cells lose their typical morphology and become more like smooth muscle cells. This change in cellular properties indicates that endothelial–to–mesenchymal transition (EndMT) is operative in vein graft stenosis.

This study will be published March 12 in Science Translational Medicine.


Zee News – Health Wealth Show

Dr kk Aggarwal on Zee Show

Safe Drugs-Health Wealth Zee News Show
Cancer Prevention–Health Wealth Zee News Show2
Potbelly Obesity–Health Wealth Zee News Show
Cancer Prevention–Health Wealth Zee News Show1
Vitamin D Health Wealth
Pneumonia–Health Wealth Zee News Show
Sudden Cardiac Death
Can Alcohol be Prescribed as Medicine
Health Wealth: All about Paralysis

cpr10 Mantra The CPR 10 Mantra is – "within 10 minutes of death, earlier the better; at least for the next 10 minutes, longer the better; compress the centre of the chest of the dead person continuously and effectively with a speed of 10×10 i.e. 100 per minute."

cpr 10 mantra
VIP’s on CPR 10 Mantra Video
Ringtone – CPR 10 Mantra Hindi
Ringtone – CPR 10 Mantra English

Mindfulness meditation

sprritual blog

Sit on a straight–backed chair or cross-legged on the floor.

Focus on an aspect of your breathing, such as the sensation of air flowing into your nostrils and out of your mouth, or your belly rising and falling as you inhale and exhale.

Once you’ve narrowed your concentration in this way, begin to widen your focus. Become aware of sounds, sensations, and ideas.

Embrace and consider each thought or sensation without judging it good or bad. If your mind starts to race, return your focus to your breathing. Then expand your awareness again.

cardiology news

The perfectionist sculptor

A gentleman once visited a temple under construction where he saw a sculptor making an idol of God. Suddenly he noticed a similar idol lying nearby. Surprised, he asked the sculptor, "Do you need two statues of the same idol?"

"No," said the sculptor without looking up, "We need only one, but the first one got damaged at the last stage." The gentleman examined the idol and found no apparent damage. "Where is the damage?" he asked.

"There is a scratch on the nose of the idol." said the sculptor, still busy with his work. "Where are you going to install the idol?" The sculptor replied that it would be installed on a pillar twenty feet high.

"If the idol is that far, who is going to know that there is a scratch on the nose?" the gentleman asked. The sculptor stopped his work, looked up at the gentleman, smiled and said, "I know it and God knows it!"

Moral: The desire to excel should be exclusive of the fact whether someone appreciates it or not. Excellence is a drive from inside, not outside. Excel at a task today – not necessarily for someone else to notice but for your own satisfaction.

News Around The Globe

  • The US Food and Drug Administration has recently accepted the application for the supplemental new drug apixaban (Eliquis, Bristol–Myers Squibb/Pfizer) for the prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE) in adults who have undergone hip- or knee-replacement surgery. Apixaban is already FDA–approved for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF).
  • According to a new report published in Diabetologia, cancer patients with diabetes have an increased mortality risk as compared to non–diabetics. The mortality rate is the highest in those using insulin. The study reported that patients, who had diabetes for 2 years and had been treated with insulin at the time of cancer diagnosis, had a 4–fold higher mortality rate than non–diabetics.
  • Vaginal mesh repair fares better than native tissue repair when it comes to anatomic failure rates, reports a recent Czech study. Kamil Svabik and colleagues noted that women with post–hysterectomy prolapse with levator ani avulsion had lower anatomic failure rates after vaginal mesh repair as compared to native tissue sacrospinous fixation. Of the 70 women with prolapse in association with levator ani avulsion injury, only one clinical anatomic failure was noted among the 36 women who had undergone mesh repair (3%), compared with 22 failures among the 34 women subjected to native tissue vaginal repair.
  • The no–touch technique for pancreatic ductal adenocarcinoma appears better than the conventional standard pancreaticoduodenectomy in terms of the number of circulating tumor cells (CTCs) in the portal vein, reports a study published in JAMA Surgery. Patients requiring curative surgery for pancreatic ductal adenocarcinoma were included in the study. The survival benefits, however, were not different between the two groups.
  • Levels of total tau protein in blood shortly after a head injury were not only diagnostic for clinically definite concussion, but were significantly predictive of persistent symptoms. In a study of 288 Swedish pro hockey players, including 28 who experienced concussions, median total tau (t–tau) in blood samples taken 1 hour after injury in the concussed players was 10 pg/mL (range 2–102), compared with 4.5 pg/mL in preseason samples taken from 47 other players. The area under the receiver–operating characteristic curve (AU–ROC) for elevated t–tau at 1 hour post injury (vs the average measured in a group of players after a noncompetitive "friendly" game) to diagnose concussion was 0.80. The study findings were published in JAMA Neurology.

CPR 10 success stories

1. Hands–only CPR 10 English

2. Hands–only CPR 10 (Hindi)

3. Ms Geetanjali, SD Public School Successful Story

4. Success story Ms Sudha Malik

5. BVN School girl Harshita does successful hands–only CPR 10

6. Elderly man saved by Anuja

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Rabies News (Dr. A K Gupta)

What is the importance of pre–exposure vaccination?

Pre–exposure vaccination simplifies post–exposure vaccination because after bite, those who have received full pre–exposure vaccination require only two doses of vaccine at Days 0 & 3. RIG is not required (WHO 2007).

cardiology news

(Dr KK Aggarwal, Group Editor in Chief, IJCP Group of Publications and eMedinewS)

  • Nasal dilation can ease symptoms in neonates with congenital nasal pyriform stenosis (CNPAS), according to a new four–patient series published online March 6 in JAMA Otolaryngology–Head & Neck Surgery. First described in 1988, CNPAS is a narrowing of the nasal cavity near the pyriform aperture, either due to medial positioning or maxillary process overgrowth.
  • Children suffering from a severe degenerative genetic disease, mucopolysaccharidosis type IIIA (MPSIIIA), may benefit from injections of adeno–associated viral (AAV) vector carrying a normal copy of the N–sulfoglycosamine sulfohydrolase (SGSH) gene, reported a recent study. The researchers of the study reported this to be a novel approach for treating CNS manifestations of lysosomal storage diseases
cardiology news

(Dr KK Aggarwal, Group Editor in Chief, IJCP Group of Publications and eMedinewS)

  • Marriage reduces your risk of dying from heart disease; and this applies to both men and women. Previous research revealed that married men have a lower risk of death from heart disease than unmarried men. However, a recent study published in the journal BMC Medicine says that married women are 28% less likely to die from heart disease than unmarried women.
  • Significant results from a study report that for every minute that the treatment of stroke is accelerated, the patient gains another 1.8 days of healthy life. Every minute is therefore important. Of note, younger patients are at increased benefit as compared to older patients. The researchers also pointed that tissue plasminogen activator (tPA), used to treat ischemic stroke, should be administered within 4.5 hours of onset of symptoms. However, the sooner it is initiated, the better results you get.
cardiology news

Ten ways to ease neck pain

  1. Don’t stay in one position for too long.
  2. Position your computer monitor at eye level.
  3. Use the hands–free function on your phone or wear a headset.
  4. Prop your touch–screen tablet on a pillow so that it sits at a 45° angle, instead of lying flat on your lap.
  5. Keep your glass prescription up to date otherwise you tend to lean your head back to see better.
  6. Don’t use too many pillows as they can stifle your neck’s range of motion.
  7. Before you move a big armoire across the room, consider what it might do to your neck and back, and ask for help.
  8. Get a good night’s sleep.
cardiology news

Total CPR since 1st November 2012 – 88792 trained

Media advocacy through Web Media

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press release

Spread the message of Holi: Communicate to remove mental impurities

Holi is a festival of love and joy and should be used as a medium of communication to remove mental dirt and impurities and cleanse the mind, said Padma Shri, Dr. B C Roy National Awardee & DST National Science Communication Awardee, Dr. K K Aggarwal, President Heart Care Foundation of India and Sr National Vice President Indian Medical Association. Holi festival should not end up with quarrels, violence or eve teasing, he further added.

Unsafe Holi

  • Green and bluish green chemicals contain malachite green, which can be toxic to the eyes. Auramine, methyl violet, rhodamine and orange II are all phototoxic colours and can damage the skin.
  • Mica in Holi colours can damage the skin.
  • Instead of chemical dyes, use floral dyes. Flowers like Marigold, China rose, Butterfly Pea, Flame of the Forest etc. are used for extraction of colours.
  • ‘Bhang’ or cannabis can precipitate acute abnormal mental behavior and psychosis. In the susceptible individuals, it can increase the heart rate and blood pressure. Pre treatment with a beta blocker can take away the bad effects of bhang.
  • Alcohol can impair judgment and make prone to accidents.
  • Balloons can cause blunt injuries to the eyes and precipitate head injuries.
  • Beware of date rape drugs. Do not play Holi with strangers.
  • Do not throw colour at sensitive parts of the body, such as eyes. If colour enters the eye, immediately wash it with a lot of water. If irritation persists, medical aid should be sought immediately.

Some tips

  • Use dental caps to protect teeth from staining.
  • Use sunglasses to keep eyes safe from the harmful chemicals of the colours.
  • Wear old and ragged clothes that may be discarded.
  • Wear full–sleeved T–shirts or shirts and leggings that fully cover the legs.
  • Wear socks.
  • Brightly coloured and dark coloured clothes should be preferred.
  • Keep your eyes and lips tightly closed, when colour is being applied on you.
  • Apply a thick layer of any oil on your body and hair till they glisten to make the skin slippery. This will help wash off colours easily later on.
  • While washing off the colour, use lukewarm water and keep eyes and lips tightly closed.
  • While traveling, keep the car windows tightly shut.
  • Use a hat, cap to protect the hair from being coloured with hard–to rinse dyes/colours.
  • If you venture out on the streets, avoid mob frenzy.
  • Do not bump into the frenzied group of mob if you take to streets. Cross the road to the sidewalk across. Or, simply stay at a safe distance.
  • Discourage children to play Holi with eggs, mud or gutter water.
  • Avoid use of abir as it has flakes of mica.
  • Stop children from forcibly applying colour on a hesitant neighbor.
  • Don’t walk alone on the streets on the day of Holi.
  • Use only natural colour and water.
  • Keep a big bucket of clean water handy for your children, so that they do not resort to gutter water and other unclean sources.

About HCFI : The only National Not for profit NGO, on whose mega community health education events, Govt. of India has released two National Commemorative stamps and one cancellation stamp, and who has conducted one to one training on" Hands only CPR" of 88792 people since 1st November 2012.

The CPR 10 Mantra is – "Within 10 minutes of death, earlier the better; at least for the next 10 minutes, longer the better; compress the centre of the chest of the dead person continuously and effectively with a speed of 10×10 i.e. 100 per minute."

emedipicstoday emedipics

CPR–10 Training Camp at Press Club–8th March 2014

press release

Vowel chanting produces aspirin in my body

vedio of day

today video of the dayPadma Shri & Dr B C Roy National Awardee,Dr KK Aggarwal on Tackling tension headaches

Hands only CPR 10 Utsav, 15th December 2013

Dr KK Aggarwal receives Harpal S Buttar Oration Award from Nobel Laureate Dr Ferid Murad

eMedi Quiz

At the end of a balanced anaesthesia technique with non–depolarizing muscle relaxant, a patient recovered spontaneously from the effect of muscle relaxant without any reversal. Which is the most probable relaxant the patient had received?

1. Pancuronium.
2. Gallamine.
3. Atracurium.
4. Vecuronium.

Yesterday’s Mind Teaser: All of the following statements regarding bio availability of a drug are true except:

1. It is the proportion (fraction) of unchanged drug that reaches the systemic circulation.
2. Bioavailability of an orally administered drug can be calculated by comparing the Area under Curve) after oral and intravenous administration.
3. Low oral bioavailability always and necessarily means poor absorption.
4. Bioavailability can be determined from plasma concentration or urinary excretion data.

Answer for yesterday’s Mind Teaser: 1.Glyceraldehyde–3–phosphate dehydrogenase.

Correct answers received from: .Dr Jainendra Upadhyay, Dr Avtar Krishan, Dr.Bitaan Sen & Dr.Jayashree Sen

Answer for 15th March Mind Teaser: 3.Low oral bioavailability always and necessarily mean poor absorption.

Correct answers received from: Dr Jainendra Upadhyay

Send your answer to ijcp12@gmail.com

medicolegal update

Click on the image to enlarge

medical querymedical query

medicolegal update
medicolegal update

Daughter in College

Did you hear about the banker who was recently arrested for embezzling $100,000 to pay for his daughter’s college education?

As the policeman, who also had a daughter in college, was leading him away in handcuffs, he said to the banker, "I have just one question for you. Where were you going to get the rest of the money?"

medicolegal update

Click on the image to enlarge

medicolegal updatemedicolegal update

medicolegal update

Situation: A dengue patient with BP 100/90 developed shock.
Reaction: Oh my God! Why was rapid fluid challenge not given?
Lesson: Make sure that pulse pressure (upper minus lower blood pressure) is maintained above 40 in all patients with dengue

medicolegal update

Determine what specific goal you want to achieve. Then dedicate yourself to its attainment with unswerving singleness of purpose, the trenchant zeal of a crusader. Paul J. Meyer

medicolegal update

Dr KK Aggarwal: Weight gain precedes the onset of diabetes Weight gain after age of 18 years in women and 20 years in men (cont) http://bit.ly/15QdVeB #Health
Dr Deepak Chopra: Who is the most powerful person in your life? What are the characteristics of a powerful person? http://bit.ly/15QdVeB #Health

medicolegal update
  1. Dear Sir, Happy Holi. Regards: Dr Kartik

Forthcoming events

Date: Saturday 2PM–Sunday 3PM, 26–27 April 2014
Venue: Om Shanti Retreat Centre, Bhora Kalan, Pataudi Road, Manesar
Course Directors: Padma Shri and Dr B C Roy National Awardee Dr K K Aggarwal and BK Sapna
Organisers: Heart Care Foundation of India. Prajapati Brahma Kumari Ishwariye Vidyalaya and eMedinews
Facilities: Lodging and boarding provided (one room per family or one room for two persons). Limited rooms for first three hundred registrants.
Course: Meditation, Lectures, Practical workshops
Atmosphere: Silence, Nature, Pyramid Meditation, Night Walk
Registration: SMS– Vandana Rawat – 9958771177, rawat.vandana89@gmail.com
SMS – BK Sapna 9650692204, bksapna@hotmail.com

Note: Donation in Favor of Om Shanti Retreat Centre will be welcomed

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