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Editorial (Dr SS Agarwal, Dr K K Aggarwal)
16th July 2016
Updated HIV guidelines integrate treatment and prevention 
 
The International Antiviral Society-USA panel on antiretroviral (ARV) drug therapy for HIV infection has released updated recommendations, which for the first time, have integrated treatment and prevention. The guidelines say that ARVs remain the cornerstone of HIV treatment and prevention and when used effectively, currently available ARVs can sustain HIV suppression and can prevent new HIV infection. 
 
The guidelines “Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults2016 Recommendations of the International Antiviral Society–USA Panel” are published July 12, 2016 in JAMA.
 
Some key recommendations are:
  • Antiretroviral therapy (ART) should be started in all individuals with HIV infection with detectable viremia regardless of CD4 cell count.  
  • The recommended optimal initial regimens include an integrase strand transfer inhibitor (InSTI) + 2 nucleoside reverse transcriptase inhibitors (NRTIs). Other effective regimens include nonnucleoside reverse transcriptase inhibitors or boosted protease inhibitors with 2 NRTIs.
  • ART should be started within the first 2 weeks after diagnosis for most acute opportunistic infections, with the possible exception of acute cryptococcal meningitis.
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Press Release
Smoking and Clopidogrel may not go together
 
New Delhi, July 15, 2016: "Clopidogrel is an important antiplatelet (anti-clotting) drug effective in preventing thrombotic (heart attack) events, especially for patients undergoing percutaneous coronary intervention (balloon angioplasty)," said Padma Shri Awardee Dr KK Aggarwal - President Heart Care Foundation of India (HCFI) and Honorary Secretary General IMA.
A study from the Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman, Jordan, published in the Journal of Clinical Pharmacy and Therapeutics has concluded that smoking is a significant factor affecting the pharmacokinetics of clopidogrel,
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