(incorporating eIMA News)
12th March 2016
Editorial (Dr S S Agarwal, Dr K K Aggarwal)
PCSK9 as a CVD Biomarker for cardiovascular disease

Approval of PCSK9 inhibitors as cholesterol-lowering drugs featured among the top stories in cardiology last year. Research has now ascribed another role for PCSK9 – as a biomarker for cardiovascular disease (CVD).

A study published online in the journal Circulation says that serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels predict risk of cardiovascular events even after adjustments for established CVD risk factors.

The prospective cohort study enrolled 4,232 men and women aged 60 years and who were free of CVD and showed that subjects with higher baseline serum PCSK9 levels were at a much higher risk of developing incident CVD within 15 years of follow-up compared to those with the lowest levels of PCSK9. This association remained significant even after adjustment for other established CV risk factors such as hypertension, diabetes, obesity, LDL cholesterol.

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Annals of the Rheumatic Diseases Update: Patients with psoriasis have high prevalence of subclinical inflammation 
JACC: Cardiovascular Interventions Update: Percutaneous septal ablation may be safe in the young too 
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Lifestyle Updates
eWellness: OTC does not mean that these drugs can be taken without a doctor’s advice
An over–the–counter antacid is often used to relieve mild cases of heartburn or acid reflux. Though they are available without a doctor’s prescription they should be taken only under a doctor’s advice. As per American...Read more

eSpiritual: Why are coconut and the kalash used in all poojas?

If nature wanted you to drink coconut water in non-coastal areas it would not have grown coconuts in the coastal areas is a common naturopathic saying. Coconut water is the treatment for most humidity-related illness in coastal areas. It is sterile water and has been...Read more

Inspirational Story: House of 1000 Mirrors 
There was place known as the House of 1000 Mirrors. A small, happy little dog learned of this place and decided to visit. When he arrived, he bounced happily up the stairs to the doorway of the house...Read more
Questions Answered By KOL's
Second Opinion Required

Dr Ankit Sahni - Pt with heart failure and gout. Gout has settled. Should I treat any asymptomatic hyperuricaemia? Should I treat to a target serum uric acid level? 

Dr Vikram Sanghi - 70 yr  male with type 2 diabetes since 6 years. On metformin extended release 2.0 grs daily. No major cardiovascular disease. Last 2 routine HBA1C levels, within a 4 month period by his GP were stable at 9.1%. Would you alter the anti-diabetic treatment? 
Press Release
IMA Starts Nodal center for adverse drug reactions
New Delhi, March 11, 2016: IMA PvPI Initiative has started a nodal center at IMA headquarters. All IMA members can now report adverse reactions to drugs, vaccines, medical devices, Blood products and herbal products at IMA PvPI helpline 9717776514, open Monday to Friday 9-5.30PM They can also call 18001803024.

Clinical trials only detect common adverse drug reactions as less than 500 human subjects are involved in any trial. Even 1 Adverse Drug Reaction of medicine in 10,000 populations is considered as unsafe.

Adverse Drug Reactions can be known or unknown, serious or non-serious due to drugs, vaccines, devices and blood products. If any doctor finds their patient vomiting, suffering from stomach pain, excessive itching, rashes, a severe headache, or high fever after taking any drug report, they must report an adverse event to safeguard their patients. Reporting even one adverse drug reaction can go a long way in safeguarding the overall health and safety India’s 1.2 billion population,” said Dr SS Agarwal – National President IMA & Padma Shri Awardee Dr KK Aggarwal – Honorary Secretary General IMA.

An adverse drug reaction (ADR) is an injury caused by taking a medication. ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs. Most adverse drug reactions are dose-related; others are allergic or idiosyncratic. Dose-related ADRs are usually predictable; ADRs unrelated to dose are usually unpredictable.
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IMA Updates
IMA Polio Dates
  • April 1st: tOPV would not be available after this date.
  • April 11th: bOPV would be available in private market but it is not to be opened or used before 25th April.
  • April 25: IMA Polio Switch Day, when tOPV would be completely withdrawn and replaced by bOPV in both routine immunization and polio campaigns.
  • 9th May: IMA National Validation Day when India would be declared free of tOPV. 

IMA Satyagraha - https://www.youtube.com/watch?v=UV1zCH33BlU

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The Indian Medical Association (IMA) presents a series of weekly webcasts for the benefit of the Indian medical profession, engaging you with the latest in advocacy efforts for doctors, through an interactive exclusive digital webcast partnership with eMediNexus.

Next Webcast: 17th
 March 2016