News and Views
Nitoglycerin for prostate cancer
Treatment of prostate cancer with very low dose of nitroglycerin may slow and even halt the progression of the disease, Queen’s University researchers report. The 24–month, phase II study targeted 29 men with increasing levels of prostate–specific antigen (PSA) following prostate surgery or radiation. PSA levels are a key predictor of cancer progression. As per Robert Siemens, the leader of the study and a Professor of Urology at Queen’s University and urologist at Kingston General Hospital, the men were treated with a low–dose, slow–release nitroglycerin skin patch and their PSA levels were monitored. Of the 17 patients who completed the study, all but one showed a stabilization or decrease in the rate of cancer progression, as measured by their PSA Doubling Time. This trial was based on a key finding from pre–clinical research carried out at Queen’s, which showed that decreases in nitric oxide play an important role in tumor progression and that this progression can be stopped by low–dose nitroglycerin. (Urology 2009;74(4):878–83)
What is Schizophrenia?
Schizophrenia is a complex, life–shortening, and frequently debilitating neuropsychiatric disorder characterized by early onset, high comorbidity rates, poor medication adherence, significant morbidity, and a relapsing–remitting course that often includes hospitalization. most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking with significant social or occupational dysfunction.
Radiation from airport scanners too low to pose danger
An editorial published in the BMJ states that consumers need not worry about the radiation dose from an airport scanner. The machines produce so little low intensity X–ray radiation that a person would have to undergo 1,000 to 2,000 screens to receive radiation similar to one chest X–ray. The machines are even safe for children and pregnant women.
Consuming large amounts of fat may raise stroke risk for women over 50
There is 30% greater risk of stroke among women eating the most trans fats, which is common in stick margarine, fried foods, crackers, and cookies. Study determines cervical cancer vaccine may not be benefit women over 40. A new study published in the Journal of the National Cancer Institute has determined that the vaccine for HPV may not be very beneficial for women older than 40.
Stroke rising among younger adults, decreasing among elderly
More and more young people (<45 yrs) these days have strokes while older people are reporting fewer such episodes. The average age of stroke patients in 2005 was nearly three years younger than the average age of stroke patients in 1993–1994. The percentage of people 20 to 45 having a stroke was up to 7.3 percent in 2005 from 4.5 percent in 1993–1994. (Dr Brett M. Kissela, Associate Professor, Co–Director of the Neurology Residency Program, and Vice–Chair of Education and Clinical Services at the University of Cincinnati Neuroscience Institute)
Stop the sale of electronic mosquito repellents
A campaign to stop the sale of electronic mosquito repellents by major airlines is beginning to bear fruit with the immediate withdrawal of the products from KLM flights. These electronic repellents, sold to airline passengers, many on their way to malaria endemic countries, just don’t work.
Treat egg allergies with eggs
Children with egg allergies, who consume increasingly higher doses of egg protein, appear to gradually overcome their allergies, tolerating eggs better over time and with milder symptoms, according to research conducted at Johns Hopkins Children’s Center.
Most deviations from guidelines may be correct
According to an observational study published in the journal Annals of Internal Medicine, physician–recorded medical exceptions are correct most of the time. In the setting of a large internal medicine practice, physicians recorded 650 standardized medical exceptions i.e. documenting medical reasons for deviating from recommendations put forth by guidelines, during a period of seven months. The reporting tool was used without any medical reason 36 times (5.5%). Of the remaining 614 exceptions, a peer–review panel classified 93.6% as medically appropriate, 3.1% as inappropriate, and 3.3% as having uncertain appropriateness. After physicians received direct feedback about inappropriate exceptions, 8 of 19 (42%) changed management. (Source: Ann Intern Med 2010;152:225–231)
FDA approves Norvir in Tablet formulation
The tablet form of Norvir (ritonavir) has been approved by the FDA. Norvir is indicated for treatment of HIV infection. Norvir has been previously available in soft–gel–capsule and oral–solution formulations. Norvir tablets are to be taken with meals, while capsules are not required to be taken with meals. Also, unlike the capsules, the new 100–mg Norvir tablets are heat–stable and do not require refrigeration.
PCOS & The Syndrome X
Date: March 19–21, 2010
Venue: Goa Marriott Resort, Miramar Beach, Goa, India
Quote of the Day
Who rises from prayer a better man, his prayer is answered. (George Meredith)
Alpha–glucosidase inhibitors can be given in diabetes Type 1 and in post prandial hyperglycemia. It causes flatulence. Miglitol and acarbose are alpha–glucosidase inhibitors.
Public Forum (Press Release)
Guidelines about Eating
Malnutrition and wrong dietary habits have been identified as major risk factors for ill health, including heart attacks. Most people below the poverty line suffer from malnutrition due to lack of calories, proteins and vitamins in their food. In the affluent society overeating or eating wrong food results in overnutrition, a form of malnutrition leading to heart blockages.
In this context Heart Care Foundation of India (HCFI) has formulated guidelines about eating said Dr. K K Aggarwal, President, Heart Care Foundation of India and Editor eMedinewS.
Eat only when you are hungry.
Do not eat for pleasure, social obligations or emotional satisfaction.
Eat at a slow pace
Eat less; dinner less than lunch.
Take small mouthfuls each time, chew each morsel well, swallow it and only then take the next morsel.
Do not eat while watching television, driving a car or watching sports events. The mind is absorbed in these activities and one does not know what and how much one has eaten.
Do not talk while eating and never enter into heated arguments. The stomach has ears and can listen to your conversation. It will accordingly send signals to the mind and heart.
Plan and decide in advance what and how much food you will be eating.
Use low fat or skimmed mild dairy products. For cooking, use oils which are liquid at room temperature.
Do not take red meat and if you are a non-vegetarian, you may take poultry meat or fish.
Question of the day
How is the temperature of a child measured? (DR G M Singh)
Normal temperature is 98.40F. Do not give much thought to such exact readings as it may show mild deviation between 36° and 36.8° C (97.7° to 99.1°F). Temperature can be taken by placing the thermometer into the child’s mouth, under their arm or using strips that are placed on the forehead. The thermometer under the tongue will take two to three minutes to read the temperature. If the child has just eaten anything hot or cold, wait for 10 minutes before an accurate temperature can be taken. This method is not suitable for a young child. They may bite the thermometer and break it, which is very dangerous. Thermometer strips, which can be placed on the child's forehead, have become very popular, but their readings are not very precise and they are not recommended. The temperature of their surroundings very easily affects a child's body temperature.
eMedinewS Try this it Works
Ethyl chloride substitute found in office product
Ethyl chloride is often used to anesthetize the skin before incision and drainage of small skin abscesses. Tetrafluoroethane in a canister, used to remove dust from personal computers, can serve as a handy substitute.
Dr Good Dr Bad
Situation: A diabetic of 20-year duration came for a routine check up. Dr Bad: Get blood sugar done.
Dr Good: Also, get your sugar, eye and kidney check up done. Lesson: The risk of cataract increases with increasing diabetes duration and severity of hyperglycemia. Data from the Beaver Dam Eye Study, the Blue Mountains Eye Study, and the Visual Impairment Project, have documented associations between diabetes and cataract. (Source: Diabetes Care 2008;31:1905–1912)
Situation: A diabetic hypertensive was denied a beta–blocker because of traditional teaching.
Reaction: Oh my God! You should have used nebivolol.
Make sure that diabetics are not denied beta–blockers when indicated. Nebivolol has no effect on glucose metabolism unlike atenolol. (Source: Am J Hypertens 2005;18 (12, pt. 2):169S–176S)
DIRECT TAXES INDIVIDUAL
Income tax slabs for any other individual taxpayers to be as follows:
Income upto Rs 1.6 lakh
Income above Rs 1.6 lakh and upto Rs. 5 lakh
Income above Rs.5 lakh and upto Rs. 8 lakh
Income above Rs. 8 lakh